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KMID : 0352419920110020227
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Keimyung Medical Journal
1992 Volume.11 No. 2 p.227 ~ p.236
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Effect of Parenteral Administration of Endotoxin on Changes of Hepatic Cathepsin B, D, H and Acid Phosphatase Activity in Rats
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Abstract
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The mechanism of hepatic damage by lysosomes, especially the role of lysosome in endotoxic shock and the relationship between lysosomal enzymes and morphologic changes of the hepatocyte was studies through measuring the activity of lysosomal mark
enzymes; cathepsin B, D, H and ACP.
Cathepsin B and D activity showed a significant increase beetween 3 and 8 hours after endotoxin administration. And catepsin H activity showed a significant increase only at 3 hours after endotoxin administration.
Lysosmal ACP activity showed a significant increase beetween 3 and 8 hours after endotoxin administration. And cytosolic ACP activity showed a significant increase only at 3 hours after endotoxin administration. But microsomal ACP activity showed
no
significant changes thorugh the experiment.
Based on the results above, the biosynthesis and the catalytic activities of the cathepsin B, D, H and ACP are increased in order to remove the necrotic tissues by endotoxin. And the damaged lysosome causes the result that the lysosomal enzymes
leak
into the cysotol in early stage, and these lysosomal enzymes in the cytosol cause the morphologic changees of the liver.
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